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They are produced by different types of cells and, once released in the body, induce specific reactions in adjacent cells (paracrine effect), in others far away (endocrine effect) or in those that have created them (autocrine effect)

Moreover, exogenous extracellular NAMPT was reported to promote the expression of profibrotic molecules in various types of renal cells [245,246], and an overexpression of endogenous NAMPT presumably induces glomerular inflammation and fibrosis [245]

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Return to activity depends upon the grade of the injury

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Yes, many researchers prefer this approach