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Men in the prison study developed the first signs of scurvy about four weeks after starting the vitamin C-free diet, whereas in the British study, six to eight months were required, possibly because the subjects were pre-loaded with a 70 mg/day supplement for six weeks before the scorbutic diet was fed
Dose escalation, hydration, meal size, nutrition, reflux history, other medications, and individual response can all influence tolerability
GLP-1 medications work by slowing digestion and increasing feelings of fullness regardless of meal timing
The glucagon receptor agonism in retatrutide introduces additional considerations not seen with GLP-1-only agents