Usage of nutritional supplements for individuals with Down syndrome
doi: 10.1016/j.phymed.2022.154615 Summary Keywords Scrophulariae Radix , endocrine disorders, thyroid diseases, diabetes mellitus, pharmacological effects, mechanisms Citation Song J, Li J, Shi H, Liu H, Qu Y and Wang F (2025) The mechanism and application of Scrophulariae Radix in the treatment of endocrine disorders: focusing on thyroid diseases and diabetes mellitus
Molecular docking and biochemical studies indicate that luteolin interacts with estrogen receptor- (ER-) and estrogen receptor- (ER-) within their ligand-binding domains ( At the receptor level, luteolins differential binding to ER- and ER- allows it to function as a weak phytoestrogenic selective estrogen receptor modulator (SERM), displaying partial agonist activity in estrogen-deficient environments and antagonistic effects under estrogen-excess conditions ( 5.6 Integrated cross-talk and systems-level regulation The pathways described above operate as an integrated signaling network rather than isolated linear cascades
The International Society of Sports Nutrition (ISSN) supports its use as an ergogenic aid, showing that it improves strength, power, and sprint performance
111 (6): 8316 Klein BE, Klein R, Linton KL
PMID 28405070
