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In addition to supplementation, diet changes may be recommended

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The patients at highest risk were those on higher doses, those with pre-existing borderline B12 levels, those with a history of metformin use (which independently depletes B12), and those over age 60

This widespread insufficiency provides a logical rationale for choline supplementation: correcting a common dietary gap may help restore normal fat-processing function in the liver

However, the technology requires specialized equipment and training that limit widespread implementation (Alcazar et al., 2011)

Gary Dunbar, a neuroscientist at Central Michigan University, has had to retract a paper on Alzheimers disease while in the midst of trying to replicate its findings