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In some cases, manufacturer direct-to-consumer pricing can fall below an employer's net cost through the traditional pharmacy channel, but switching channels can affect rebates, contract guarantees, and clinical management in ways that may not be immediately visible

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doi: 10.1038/ng0595-111 58

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In Taiwan and the United Kingdom, T1DM population cohort studies revealed that the risk of epilepsy in the T1DM population was approximately 3 times greater than that in the control population (77, 78)