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Altered functional connectivity between the amygdala and vmPFC neural circuit is also observed in rodents after traumatic events, leading to the pathophysiology of PTSD (Liang et al., 2014)

Toxicol Pathol 35, 92841

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A larger phase 2b trial by Metabolic Pharmaceuticals (the original sponsor) in 2007 with 534 obese patients failed to show statistical superiority over placebo at 24 weeks