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DPP4 extracelullar structure consists of two domains comprised of a eight -bladded -propeller domain and a C-terminal ,-hydrolase domain with the catallytic triad (Asp708, His740, Ser630) (Rhrborn et al., 2015)

It will focus specifically on CagriSema, which combines two hormone-mimicking molecules into a single, weekly injection

Importantly, other medications commonly prescribed alongside semaglutide may cause increased urination, particularly SGLT2 inhibitors (like empagliflozin, dapagliflozin) and diuretics

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These include structured lifestyle interventions and behavioural support through NHS Tier 3 weight management services (information available at nhs.uk), as well as licensed pharmacological treatments where clinically appropriate including orlistat, semaglutide (Wegovy, subject to NICE Technology Appraisal TA875), and tirzepatide (Mounjaro, subject to NICE Technology Appraisal TA1026)