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When they become severe, heavy metal poisoning symptoms can even mimic symptoms associated with Alzheimers disease, Parkinsons disease and multiple sclerosis

doi:10.3390/ijms23010119 29

The key site for lipid and glucose metabolism, calcium homeostasis, detoxifying drugs, and metabolisms is the central processing unit responsible for protein translation, folding, and modification ( UPR is mediated by a partner molecule specific for the endoplasmic reticulum, namely glucose-regulated protein78(GRP78), and three transmembrane protein stress sensors ( Figure 3 )

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[68] reported that psoriatic lesions expressed high Nrf2 levels and low GPX4 levels