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Reiniers MJ, van Golen RF, van Gulik TM, Heger M (2014) Reactive oxygen and nitrogen species in steatotic hepatocytes: a molecular perspective on the pathophysiology of ischemia-reperfusion injury in the fatty liver

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Caspase-8, for instance, is able to directly cleave pro-IL-1, thus activating (and not inhibiting), through signal transduction, the necroptotic pathway, which is known to culminate in cell lysis accompanied with inflammation [128]