TFAM binds to mtDNA and forms a nuclear-like structure, thereby protecting mtDNA from the adverse effects of A toxicity and oxidative stress, inhibiting the vicious cycle of neuronal mitochondrial dysfunction, and thus improving the pathophysiology of Alzheimers disease (Oka et al., 2016)
FOXO4-DRI appears to work by inhibiting FOXO4-p53 binding
Freezing lyophilized powder is generally safe and extends shelf life significantly
However, when nerve damage has progressed too far, especially with long-term axonal loss, complete reversal is less likely
There are similar findings in limited human studies, but the number of studies is still insufficient
So, we decided the study design be based on the pre-post intervention model