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Choline and methionine support hepatic function, but if liver enzyme levels (ALT, AST) are elevated, your doctor may recommend baseline labs, lower initial doses, or concurrent dietary modifications (reduced fructose, increased omega-3 intake) before introducing the injections

Supplementation is most impactful in individuals with compromised hepatic glutathione stores NAFLD, alcohol use, chronic medication exposure, or environmental toxin burden

This combination is often used for people with Type 2 diabetes who need more than one medication to keep their blood sugar in check

Importantly, these strategies must be compartment-aware, as the same node can cut both ways in cancer versus immune cells (152)

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