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Schmidt started Zepbound and found her symptoms improved so significantly that she used the term miraculous, with her symptoms falling to a 6 out of 132 on the Post-Concussion Symptom Scale

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Also published in the New England Journal of Medicine in 2022, the SURMOUNT-1 trial demonstrated that tirzepatide at the 15 mg dose produced an average weight loss of 22.5% of body weight over 72 weeks approaching results typically seen with bariatric surgery (Jastreboff et al., 2022, PMID: 35658024)