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The increased FAO driven by carnitine leads to an increase in intracellular acetyl-CoA levels, which can be transferred to the nucleus for acetylation of histone H3K27, thereby activating GATA3 gene expression and promoting the differentiation of triple-negative breast cancer cells to the luminal cell state [36]

74 In a small study of 14 individuals given 1000 mg daily vitamin C supplementation for 2 weeks, Otten et al

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However, the progression of hypercholesterolemia was reduced 50 % by L-carnitine administration in those animals fed cholesterol diet

Furthermore, the modeling process requires specialized feeding equipment, with experimental animals being individually housed or paired in a cage, resulting in increased experimental costs