To accelerate progress in manufactured islet cell therapies, the panelists agreed that the top priorities are: More companies exploring novel approaches Expanding eligibility criteria for trialsand incoporating the perspectives of the T1D community into regulatory decisionsso we can build more evidence around the safety and efficacy of manufactured islet cell therapies Additional frameworks to help guide the field, like our cell therapies roadmap and upcoming publications from Breakthrough T1D staff around manufacturing and preclinical considerations Optimizing manufacturing processes to reduce costs and ensure access for people who want these therapies Optimizing cell therapy products by reducing or eliminating the need for immunosuppression and finding the best transplant site for survival Brynn Marks, M.D., Senior Director of Medical Affairs, chaired a session about the promise and perspective of islet cell replacement therapies for kids with T1D
De novo NAD + biosynthetic impairment in acute kidney injury in humans
Evidence-based alternatives For people seeking effective weight management, several proven approaches offer better value than unproven patches: NHS weight management services: Free programmes available through GP referral, focusing on sustainable lifestyle changes with professional support
L-Carnitine may improve exercise performance & recovery Given its potential fat-burning capabilities, its thought that L-Carnitine optimises how your body uses fat for fuel, allowing you to exercise for longer.7 Some research has also found that three weeks supplementation with an L-Carnitine supplement reduces muscle damage from high intensity exercise bouts.7 Supplementing with L-Carnitine could also play an important role in recovery from strenuous exercise, with suggested doses of 2-4g daily to optimise results.6 Theres initial evidence that this could lead to a reduction in various markers of metabolic stress and muscle soreness which is replicated in many studies
Mftoglu M, Elibol B, Dalmizrak O, Ercan A, Kulaksiz G, Ogs H, et al
India, the United States, and China report the highest disease burdens, with India alone accounting for approximately 20 million cases [9]
