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Moderate doses within recommended dietary allowances are generally safe, but excessive supplementation is unnecessary

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A few times weekly at moderate concentrations, year after year, keeps the remodelling signals steady and the MMP/TIMP balance intact

Dietary Se intake clearly differs between regions of the world, largely due to the variable Se content of soil, as well as pH, redox, and water content of the soil, which all influence the Se uptake by growing plants, and consequently, animals exposed, as well as water and the type of food consumed by humans (45, 69)

[15] A recent study on melasma patients noted significantly higher levels of glutathione-peroxidase enzyme in patients compared to controls, confirming the role of oxidative stress in melasma