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Ferroptosis in cancers Ferroptosis and the epithelial-mesenchymal transition In vertebrates, the two basic cell types are epithelial cells and mesenchymal cells, which can transform into one another through a reversible process known as epithelialmesenchymal transition (EMT)
PGA is a degradation product of glutathione metabolism within the -glutamyl cycle and is directly associated with disruptions in GSH homeostasis and GSH depletion [44, 45, 65, 66]
Some GST enzymes possess antioxidant activity against hydroperoxides
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However, the phenomena that induce OS attributable to the patients aging, in addition to being variable in terms of intensity among individuals, are difficult to distinguish from those produced by the compromised antioxidant defense systems due to a neurodegenerative disease, such as ALS
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