(DeCampo and Moreno, 1984
FDA-approved indications
There are many agents with a well known depigmenting effect like pycnogenol, orchid extract, marine algae extract, cinnamic acid, soy, aloesin, Boswellia , hydroquinone, glycolic acid, arbutin, kojic acid, ascorbate, tocopherol, niacinamide, etc
This is one reason many pharmacies prefer higher concentrations for patients who will titrate above 5 mg
That decision would become the foundation of a two-generation Gordon family legacy father, daughter and son paving along the exact same path at the University of Maryland followed by PCO
Since the pancreas has abundant GAD, a direct immunological destruction occurs in the pancreas and the patients will have diabetes mellitus