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Assays such as ATAC-seq and ChIP-seq have identified distinct open chromatin landscapes near the BIN1 gene locus in both mouse and human microglia, marked by PU.1, H3K27ac, and H3K4me2

Hailey et al

A recent study found that intensive lifestyle modification improves cognitive and functional performance and slows disease progression in older adults with mild cognitive impairment

They spend more time in the anxiogenic open arms of the maze [155, 177]

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Engel, S