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Figure 2 5 Immune regulatory mechanisms of PEFs in the TME PEFs (IRE and nsPEF) drive anti-tumor responses by systemically reshaping the myeloid immune landscape: They significantly reduce MDSCs proportions ( + TAM-mediated immunosuppression (104), while driving the sphingolipid metabolism-mediated differentiation of Ly6c2 + monocytes into dendritic cells ( 2 NSs captures tumor antigens to form in situ vaccines that promote DC migration (105)