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The Collateral Damage: Allopregnanolone Allopregnanolone (ALLO) is synthesized in the brain from progesterone via a two-step pathway: Progesterone 5-dihydroprogesterone (via 5-alpha reductase) 5-DHP Allopregnanolone (via 3-HSD) Because 5-AR is the rate-limiting step, inhibiting it blocks ALLO productioneven when progesterone levels are adequate

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In cerebral microdialysis study in rats, significantly higher brain intracellular distribution of ketoprofen was reported after LAT1-utilizing derivative of ketoprofen compared to parent drug dosing (112)

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Peptides are short chains of amino acids the body already uses as signaling molecules