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First described back in the 1950s, acne erupts in about one in ten people within days or even hours of getting an injection of vitamin B12, which then disappears rapidly when injection treatment is discontinued. At the time, we had no idea what the mechanism might be, and the problem remained unsolved until just a few years ago when we finally figured it out: Vitamin B12 modulates the gene expression of the skin bacteria that cause acne
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Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet
[1] In cultured mouse adipocytes, exposure to a methylquinolinium NNMT inhibitor raised intracellular NAD+ and SAM and lowered lipogenesis
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