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1B,E) which had the capacity to support pregnancies and development to term (Figs

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Compound 14 should be singled out from the others, since it shows good inhibitory activity (IC 50 = 3.56 M), which is almost 2.5 times more effective than allopurinol (IC 50 = 7.86 M), a drug that has already been consolidated in the treatment of hyperuricemia (Figure 7)

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Eligible participants had CKD defined as either an eGFR of 5075 mL/min/1.73 m 2 with UACR 3005,000 mg/g, or an eGFR of 25 to 50% eGFR decline, ESKD, or all-cause mortality [81]

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references NIH Office of Dietary Supplements Carnitine Fact Sheet for Health Professionals NIH Office of Dietary Supplements Carnitine Consumer Fact Sheet Pooyandjoo et al

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