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J Pharm Pharmacol 2010;62(8):1077-1083

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In a recent, trimodal approach comprising 18 F-FDG-PET, functional MRI and 18 F-DOPA-PET, evidence was found for network-dependent neurodegeneration in PD by recapitulating the impact of nigrostriatal pathway impairment on putaminal dopamine depletion to striatocortical motor circuit dysfunction, thus providing a biomarker for the quantification of disease progression (Ruppert et al

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However, this approach inevitably limits the generalizability of our findings, as sex may influence gut microbiota composition, immune response patterns, and central nervous system inflammatory processes