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Li, R., Patterson, K

Multiple trials show tirzepatide produces greater average weight loss than semaglutide

these molecules are typically very reactive with other molecules they come in contact with

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the numbers look larger but the design cannot support a head-to-head claim.9 In paediatric type 1 there are no Phase 3 trials at all, a gap ISPAD 2024 flags explicitly.6 Longer, larger AID-era trials with hard outcomes, paediatric data, and head-to-head tirzepatide RCTs would all strengthen it