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54,55 Functionally, these classes of drugs strongly and selectively inhibit reabsorption of glucose by renal SGLT-2, thereby resulting in glucosuria, and rearrangement of bodily hemodynamics, such as reduction of arterial blood pressure, depletion of interstitial fluid rather than blood volume that improves both preload and afterload in heart failure, and neuroendocrine factors like the RAAS system
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"The antidepressant effect of an antiulcer pentadecapeptide BPC 157 in Porsolt's test and chronic unpredictable stress in rats." Journal of Physiology Paris
We observe that the distinct Na + and carnitine cavities are bridged by a dual glutamine motif, previously implicated in Na + activation kinetics 46
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