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Ann Clin Psychiatry (2009) 21:21336

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In silico studies predicted that HCQ and other AMDs interacted with cGAS-DNA complex at a site necessary for binding to cGAS and its activation by DNA, and in vitro experiments confirmed that quinacrine blocked the binding between dsDNA and cGAS (78)

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SAM and SAH show pathway activity Low SAM and elevated SAH represent different biochemical barriers and should not automatically receive the same treatment

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