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Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HAW

To preserve peptide stability and integrity: Although preclinical studies have not reported significant toxicity , the human safety profile remains unestablished

Pre-treatment preparation Proper preparation minimizes complications

Blood pressure improvements were observed across prespecified subgroups including participants with and without baseline hypertension

Disease-modifying therapies for ATTR-CM can be classified into three main strategies: 255 (1) stabilizing TTR tetramers to inhibit dissociation, (2) suppressing hepatic TTR synthesis, and (3) promoting the clearance of amyloid deposits via antibody-driven phagocytosis (Fig

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