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On the other hand, GSH deficiency leads to the death of RPE cells

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However, if your current effective dose is still managing your appetite well with minimal side effects, staying on it longer may be more beneficial while your body adjusts to its new weight and metabolic rate

The real catch is that it probably won't deliver what you want: stop the drug and the weight likely returns, the side effects are worth respecting, and you'd have to change your habits and your sense of yourself to hold any of it

A meta-analysis by Faraone and Buitelaar (2010) pooling data from multiple randomized controlled trials found that amphetamine-based medications had a modestly larger mean effect size (SMD 0.99) for ADHD symptom reduction compared to methylphenidate-based medications (SMD 0.78) [6]