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Pharmaceutical agents that decrease food intake, including FDA-approved GLP-1 analogs, often concomitantly promote GI discomfort, thus limiting their clinical application by developed tolerance to these aversive effects

This inhibition mode in hTYR is noteworthy, as it suggests that the search for and optimization of efficient and safe peptide-based inhibitors may become a key direction in the development of human tyrosinase inhibitors

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B12 injections are typically given in the thigh, upper arm, or buttock