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Tirzepatide (515 mg weekly) evaluated over 52 weeks in the SYNERGY-NASH trial with participants having MASH and stage F2 or F3 fibrosis showed MASH resolution without worsening fibrosis in 44%, 56%, and 62% of participants on 5 mg, 10 mg, and 15 mg doses, respectively, compared to 10% with placebo [102,107]

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These combined actions of GLP-1R signaling cause improvements in glycemic control as well as weight loss in type II diabetes (T2DM) patients treated with GLP-1R agonists