However, the largest 24-week trial with 536 participants failed to show statistically significant weight loss, which led to development termination
Patients who have undergone gastric bypass or other bariatric procedures have surgically altered anatomy that reduces the absorptive surface area in the stomach and small intestine
The threshold at which this association has been observed is serum levels over 813 pg/mL (600 pmol/L)
I recommend: at least 2,000 mcg (g) cyanocobalamin once each week, ideally as a chewable, sublingual, or liquid supplement taken on an empty stomach or at least 50 mcg daily of supplemental cyanocobalamin or a serving of B12-fortified foods three times a day, each containing at least 190 percent of the Daily Value listed on the nutrition facts label Those over 65 years of age should take at least 1,000 mcg (g) cyanocobalamin every day
The comparison is not just academic
The treatment starts with a big dose, then smaller doses are given regularly