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Semaglutide is a GLP-1 receptor agonist that enhances glucose-dependent insulin secretion, suppresses appetite via central nervous system pathways, and delays gastric emptying

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TLR1, TLR2 and TLR4 activation results in augmented mitochondrial ROS production following recruitment of mitochondria to macrophage phagosomes, leading the way to increased mitochondrial and cellular ROS generation (West et al., 2011)