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Thirty-six rats were used and divided into three experimental groups of twelve animals each

Modulation of the permeability transition pore Studies have reported that mitochondria permeabilize due to the mitochondrial permeability transition pore (mPTP) opening, a pathophysiological event that, under favorable conditions, causes an increase in permeability of the inner mitochondrial membrane and leads to mitochondrial depolarization, swelling, and the activation of the apoptotic and necrotic pathways 43

Zenaro, E

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Front Endocrinol 2

Molitch ME, Clemmons DR, Malozowski S, et al