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doi: 10.1158/0008-5472.CAN-08-4359 262 RaymanMP

Since this cascade is confined to the intracellular mevalonate-CoQ10 metabolic pathway and does not intersect with NPC1L1-mediated dietary cholesterol absorption in intestinal epithelium, and since relevant in vitro experiments were conducted under standard serum-containing culture conditions without evidence of extracellular lipid deprivation, clinically used doses of simvastatin do not attenuate its ferroptosis-promoting effects by interfering with intestinal lipid absorption

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