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Even after the medications have done their job, long-term weight loss will depend on a commitment to overall lifestyle changes and maintenance goals

Real-world data from electronic health records tells a similar story, though the gap narrows somewhat in patients who also have type 2 diabetes

Participants who continued treatment maintained significantly more weight loss than those who transitioned to placebo, reinforcing that tirzepatides benefits are dependent on ongoing use and that no new or unexpected safety signals emerged with extended treatment duration

This dual actioncontrolling both blood sugar and appetitemakes semaglutide an effective treatment for those with type 2 diabetes and those aiming to lose weight

They are also used to decide whether a given health service is medically necessary

Some patients find that taking their injection in the evening and sleeping through the peak nausea window works well