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In ALS models, SOD1 mutations do not markedly alter astrocytic baseline states but lower the threshold for reactivity, which sensitizes astrocytes to oxidative, glutamatergic and inflammatory stress and drives exaggerated reactive responses to otherwise moderate insults 80

doi: 10.1158/1541-7786.MCR-18-0055 31 SuLJZhangJHGomezHMuruganRHongXXuDet al

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An oxidase from the mushroom Armillariella tabescens was previously reported to oxidize AFB1 (Liu et al., 2001)