We propose that the formation of adducts of acrylamide with thiol groups of metabolites and proteins is the molecular initiating event (MIE) of AA neurotoxicity
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Seiwerth, S., Brcic, L., Batelja Vuletic, L., Kolenc, D., Aralica, G., Misic, M., & Sikiric, P
Ford, and M
Rolling: Place the vial between the palms of your hands and gently roll it back and forth
Materials and methods Animals and experimental design Nine-week-old male Fischer 344 rats (Charles River Laboratory, Japan), weighing from 180-200 g, were maintained at 23C, given standard laboratory chow and water ad libitum, and kept under a 12 h light (7:00-19:00)/12 h dark schedule