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Considering that very little is known about the local and temporal concentrations of NADPH and TGR and the multiple redox-associated conformational states, it is difficult to assess how accurately the biochemical assay with recombinant TGR models the inhibition of TGR in worms ex vivo or in vivo

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Tan Y, Flynn WF, Sivajothi S, Luo D, Bozal SB, Dave M, Luciano AA, Robson P, Luciano DE, Courtois ET (2022) Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues

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demonstrated that enzyme glutathione-s-transferase pi (GST-), which is present in keratinocytes and melanocytes, has a protective role against tumor progression, specifically sun exposure-associated melanoma cells