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Clinical trials on NAC in IPF have yielded mixed results: some showed slowed lung function decline [155], while a large phase 3 trial found no significant benefit in preserving forced vital capacity (FVC) in patients with mild-to-moderate IPF [156]

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Cellular functions of the protein kinase ATM and their relevance to human disease

These may include: Nausea, vomiting or diarrhoea (most common early on) Constipation Fatigue Mild increases in heart rate (similar to changes seen with GLP-1 medicines) Side effects were more frequent at higher doses (8 mg and 12 mg), but still rated mild to moderate overall

In contrast, both hCiPSC-NSCs-treated rats (Fig