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Provided steady state has been approached (at least three half-lives of constant dosing), a sample obtained near the midpoint of the dosing interval will usually be close to the mean steady-state concentration

The duration of benefits varies by formulation and individual physiology, but many clients report sustained improvements for several days to weeks following treatment

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Early reports suggest that cost trends will be higher for 2026, potentially leading to higher premium increases unless employers and plans find ways to offset higher costs through changes to benefits, cost sharing, or plan design, the KFF survey said