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While its efficacy in managing blood glucose levels and supporting weight loss is noteworthy, its crucial for patients and healthcare providers to fully understand the potential side effects associated with tirzepatide

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Conversely, some patients gain weight during remission or with corticosteroid therapy, creating complex metabolic considerations

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Its mechanism involves specific engagement of AMY1R and AMY3R in hindbrain and hypothalamic circuits that regulate energy homeostasis, leading to preferential fat mass reduction and altered hypothalamic gene expression profiles [2]

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