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Mechanistically, liver injury may result from mitochondrial dysfunction, oxidative stress, or idiosyncratic hypersensitivity reactions
Across the entire study, data from two animals were excluded: one outlier from the cisplatin alone group in the breeding trial shown in Fig
In lung cancer models, for example, liposomes and polymeric nanoparticles have been used to transport chemotherapeutic or immunomodulatory agents directly to tumor tissue, thereby improving treatment precision and reducing systemic toxicity [195]
doi: 10.1001/jama.2020.9482 169
Additional tirzepatide safety concerns include risk of acute gallbladder disease (presenting as right upper quadrant pain, fever, or jaundice), acute kidney injury from dehydration (especially if severe gastrointestinal symptoms occur), and hypersensitivity reactions
Jiang X, Gao Y, Zhou H, Chen J, Wu J, Zhang S
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