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Collectively, these findings support a bidirectional relationship in which sleep promotes mitochondrial redox homeostasis, while mitochondrial oxidative status shapes sleep quantity, quality, and circadian stability, processes with broad implications for aging and neurodegenerative diseases

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Abbreviations cAMP: Cyclic adenosine monophosphate EPAC: Exchange protein directly activated by cAMP GABA: -Aminobutyric acid GiD: Inhibitory designer GPCR GLP-1: Glucagon-like peptide 1 GPCR: G-protein-coupled receptor GSIS: Glucose-stimulated insulin secretion K ATP : ATP-dependent K + (channel) PC: Prohormone convertase PKA: Protein kinase A References Jo J, Choi MY, Koh D-S (2009) Beneficial effects of intercellular interactions between pancreatic islet cells in blood glucose regulation

Furthermore, in addition to impacting endothelial cells and curtailing the production of matrix metalloproteinase-2 (MMP-2), methylated selenium has also been shown to inhibit vascular endothelial growth factor (VEGF) expression in breast cancer cells (57)

A metabolic multistage glutathione depletion used for tumor-specific chemodynamic therapy