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Hypoxia, a feature of a subtype of MS lesions 35 , can induce GSDMD expression through phosphorylation of STAT3, which promotes nuclear translocation of programmed death ligand 1 (PDL1) 56

Notably, PKM2, the terminal rate-limiting enzyme in glycolysis, showed specific high-expression characteristics in activated CD4+ T cells

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Rest Encourage your sick child to get plenty of rest, as the body is using energy to fight off infections

Andrikou E, Tsioufis C, Andrikou I, et al