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The key principle remains the same: never increase a dose while actively experiencing significant gastrointestinal symptoms from the current one

Most of us are able to make or consume the carnitine we need, although those with kidney disease, certain genetic disorders or who follow restrictive diets may be at risk of lower levels

The gas production is dose-dependent, and even the relatively modest amount in Pendulum can cause noticeable symptoms in people who are not accustomed to high-fiber diets

Genomics 40 , 339346 (2013)

The translocation of endogenous MOTS-c to the nucleus leads to retrograde signaling in the stressed state 59,60

Cancer Res 2009;69:2117