9,12-15 A systematic review and meta-analysis of randomised controlled trials evaluating weight reduction diets, with or without exercise, reported an 18% reduction in all-cause mortality over a median follow up of two years in adults with obesity
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Metformin is a first-line diabetes medication that improves insulin sensitivity in your liver and muscles, while tirzepatide acts as a dual GLP-1 and GIP receptor agonist that slows gastric emptying and increases insulin secretion in response to meals
And emerging research suggests GIP may have protective effects on brain function and bone density, areas where pure GLP-1 agonists have raised some concerns
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[1] [2] Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist