how do glp-1 receptor agonists work Why are being used to treat patients with nonalcoholic fatty liver disease? Navigating the Limitations and Downsides

PubMed Dhillon S, Keam SJ Bremelanotide: First Approval

At the adipocyte level, CD36-mediated fatty acid uptake is acutely stimulated by Hexarelin a finding that is contextually dependent: in a lipotoxic model (HFD-fed ob/ob mice), Hexarelins CD36 activity paradoxically worsens hepatic lipid accumulation (hepatic TG +1822% at 80 g/kg), while simultaneously reducing infarct size in parallel cardiac endpoints

The protein was shown to be inactive in the HEDS assay but to react with roGFP2 (ref

[Abstract] Cell

However, some researchers do explore a hybrid model

Geisler CE, Antonellis MP, Trumbauer W, Martin JA, Coskun T, Samms RJ, et al