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There is no direct dose equivalence between the two compounds because they work through different receptor profiles

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This indicates that synthetic pentapeptide has the potential to increase bone growth in children with growth retardation [2]

Importantly, there were no dose-dependent signals for pancreatitis or thyroid C-cell tumors in the human data, though the standard rodent-derived thyroid risk noted on semaglutide and tirzepatide labels will presumably carry over to retatrutide's prescribing information pending further analysis

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