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Needed Records: Mixing date and level Use dates, times, and doses Injection sites and rotation schedule Storage conditions and heat logs Any deviations from protocol Research findings and measurements Adverse events or unexpected findings 8

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Bibbiani F, Oh JD, Petzer JP, Castagnoli N Jr, Chen JF, Schwarzschild MA, Chase TN (2003) A2A antagonist prevents dopamine agonist-induced motor complications in animal models of Parkinsons disease

Additionally, the Merck application does not disclose that a peptide-based melanocortin agonist may be administered by an intranasal route and a PDE-5 inhibitor administered by an oral route, or that the agents may be sequentially administered at timed intervals to obtain optimal results