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Originally developed for treatment of type 2 diabetes in 2004, and later approved for weight loss in 2014, GLP-1s have demonstrated clinically meaningful reductions in A1c as well as unprecedented weight loss, with patients losing up to 20% of t heir body weight. There has been rapid adoption and a surge in demand for incretin-based therapies
Chen YT, Tsai TH, Yang CC, Sun CK, Chang LT, Chen HH
Moreover, under conditions of high folate intake, 5-methylTHF reduces the alternative transmethylation pathway by inhibiting glycine methyltransferase (Fig
Treat the protocol as what it is: a community approach informed by published pharmacokinetics, still waiting on the trial evidence that would confirm or refute its tolerability claims
Benefits: Improves cognitive function
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